Drugs or Vaccines Being Tested in Patients with COVID-19

Drugs or Vaccines  in Phase 2 Clinical Trials in Patients with COVID-19

This is as of June 7, 2020.  

For the interest of understanding currently ongoing clinical trials for a list of representative drugs in patients with COVID-19, the following provides a list of drugs which are currently being tested in phase II clinical trials. In other words, this is a list of representative drugs, biologicals, plasma, or others being tested in human phase II clinical trials currently recruiting patients with COVID-19. 

The list is based on 221 clinical trials involving COVID-19 conducted around the world.  

NOTE: Each numbered item under each country represents listed drug(s) tested in a Phase II clinical trial study registered at the database of privately and publicly funded human clinical trials/studies on a global basis (ClinicalTrials.gov).  Placebo (oral tablet or saline injection) or standard care as a control is not listed.  

The names of countries are not in alphabetical order. 

United States

  1. Sarilumab
  2. Biological: anti-SARS-CoV-2 convalescent plasma
  3. Dociparastat sodium
  4. Biological: Convalescent Plasma; Biological: Lactated ringer’s solution or sterile saline
  5. Etoposide
  6. MSTT1041A/MSTT1041A-matched Placebo; UTTR1147A/UTTR1147A-matched Placebo
  7. Baricitinib and Hydroxychloroquine
  8. SNDX-6352
  9. Peginterferon Lambda-1a
  10. : PUL-042 Inhalation Solution
  11. PUL-042 Inhalation Solution
  12. Leronlimab (700mg)
  13. Biological: Convalescent Plasma (anti-SARS-CoV-2 plasma) with
    Control (albumin 5%)
  14. Favipiravir + Standard of Care
  15. Biological: Convalescent Plasma (anti-SARS-CoV-2 plasma) with
    Non-convalescent Plasma (control plasma)
  16. Hydroxychloroquine
    Hydroxychloroquine and Azithromycin
    Hydroxychloroquine and Ivermectin
    Camostat Mesilate
  17. Biological: MultiStem
  18. Tocilizumab
  19. BLD-2660
  20. Saline oral/nasal rinse
    0.5% Povidone/Iodine oral/nasal rinse
    0.12% Chlorhexidine oral/nasal rinse
  21. ATYR1923 1 mg/kg
    ATYR1923 3 mg/kg
  22. Tociliuzumab
  23. Biological: Biological: mRNA-1273: 50 mcg
    Biological: Biological: mRNA-1273: 100 mcg
  24. BMS-986253
  25. High-Titer Anti-SARS-CoV-2 (COVID 19) Convalescent Plasma
  26. N-acetylcysteine and Peripheral Blood
  27. Convalescent Plasma
  28. Hydroxychloroquine and Radiation: Radiation therapy
  29. Hydroxychloroquine
    Zithromax Oral Product
  30. Selinexor
  31.  Leronlimab (700mg)
  32. Biological: CYNK-001
  33. Canakinumab Injection 600mg and Canakinumab Injection 300mg
  34. Mavrilimumab
  35. Peginterferon lambda alfa-1a subcutaneous injection
  36. Hydroxychloroquine
  37. Drug: MethylPREDNISolone 80 Mg/mL Injectable Suspension (Puerto Rico)
  38. Veru-111
  39. Estradiol patch
  40. Biological: Convalescent Plasma
  41. Nitric Oxide
  42. Hydroxychloroquine and Azithromycin
  43. Prazosin
  44. Hydroxychloroquine (HCQ) and Calcium citrate
  45. Convalescent Plasma
  46. Hydroxychloroquine Sulfate 400 mg twice a day
    Hydroxychloroquine Sulfate 600 mg twice a day
    Hydroxychloroquine Sulfate 600 mg once a day
    Placebo oral tablet
  47. Tocilizumab
  48. Clazakizumab 25 mg
    Clazakizumab 12.5 mg
  49. Povidone-Iodine Nasal Spray and Gargle
  50. Combination Product: Hydroxychloroquine Sulfate + Azithromycin
    Drug: Hydroxychloroquine Sulfate
  51. LY3127804
  52. Gimsilumab
  53. Nitric Oxide Gas
    Other: Inhaled Supplemental Oxygen
  54. Atovaquone/Azithromycin
  55. Fluvoxamine
  56. Ibrutinib
  57. GLS-1200
  58. Hydroxychloroquine or/both
    Azithromycin to treat severe SARS-CoV-2 infection
  59. Sirukumab
  60. Naltrexone
  61. Aviptadil by intravenous infusion + standard of care
  62. Vazegepant (BHV-3500)
  63. Dipyridamole 100 Milligram(mg)
  64. TJ003234
  65. Convalescent plasma
  66. Ascorbic Acid
    Hydroxychloroquine Sulfate
    Folic Acid
  67. Hydroxychloroquine  (Columbia University)
  68. Heparin
  69. Losartan
  70. Hydroxychloroquine (University of Utah)
  71. CM4620-Injectable Emulsion
  72. Hydroxychloroquine Sulfate
    Ascorbic Acid
  73. L-ascorbic acid
  74. lopinavir/ritonavir
    Hydroxychloroquine Sulfate
  75. Umbilical Cord Mesenchymal Stem Cells
  76. Chloroquine (Columbia University)
  77. Low Dose Radiation Therapy

South Korea

  1. Clevudine and Hydroxychloroquine

United Kingdom

  1. TD-0903
  2. Interferon beta 1a
  3. Biological: Human umbilical cord derived CD362 enriched MSCs
    Biological: Placebo (Plasma-Lyte 148)
  4. Biological: Human umbilical cord derived CD362 enriched MSCs
  5. Interleukin-7
  6. nebulised recombinant tissue-Plasminogen Activator (rt-PA)
  7. Lopinavir-Ritonavir
    Biological: Convalescent plasma


  1. Biological: Low dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule
    Biological: Low dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 14-day schedule
    Biological: Medium dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule
    Biological: Medium dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 14-day schedule
    Biological: High dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 28-day schedule
    Biological: High dosage Inactivated SARS-CoV-2 Vaccine on a 0- and 14-day schedule
    Biological: Placebo on a 0- and 28-day schedule
    Biological: Placebo on a 0- and 14-day schedule
  2. Biological: NK cells,IL15-NK cells,NKG2D CAR-NK cells,ACE2 CAR-NK cells,NKG2D-ACE2 CAR-NK cells
  3. Fingolimod 0.5 mg
  4. Biological: MSCs
    Biological: Saline containing 1% Human serum albumin(solution of MSC)
  5. Biological: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule
    Biological: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule
    Biological: Two doses of placebo at the emergency vaccination schedule
    Biological: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule
    Biological: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the routine vaccination schedule
    Biological: Two doses of placebo at the routine vaccination schedule
  6. UC-MSCs
  7. Biological: allogeneic human dental pulp stem cells (BSH BTC & Utooth BTC)
  8. Injection and infusion of LV-SMENP-DC vaccine and antigen-specific CTLs
  9. N-acetylcysteine+ Fuzheng Huayu Tablet
  10. Interferon Beta-1B and Hydroxychloroquine (Hong Kong)
  11. Biological: CAStem
  12. VC
  13. Meplazumab for Injection


  1. Tocilizumab
  2. Biological: Pembrolizumab (MK-3475)
  3. Hidroxicloroquine, Lopinavir/ritonavir, Imatinib tablets, and Baricitinib Oral Tablet
  4. Siltuximab and Methylprednisolone
  5. Biological: Mesenchymal Stromal Cells
  6. Ruxolitinib plus simvastatin
  7. Tocilizumab
  8. Sarilumab
  9. Defibrotide 25 mg/kg 24 hours continuous infusion for 15 days
  10. Ivermectin
  11. Biological: Hyperimmune plasma
  12. Allogeneic and expanded adipose tissue-derived mesenchymal stem cells


  1. ABX464
  2. LEAF-4L6715 and LEAF-4L7520
  3. Transfusion of COVID-19 convalescent plasma
  4. Prednisone
  5. Eculizumab
  6. Hydroxychloroquine
  7. Chloroquine analog (GNS651)
  8. IgIV
  9. Combination Product: Hyperbaric oxygen treatment (HBOT)
  10. Biological: Umbilical cord Wharton’s jelly-derived human
  11. Hydroxychloroquine + placebo
    hydroxychloroquine + azithromycin


  1. Peginterferon Lambda-1A
  2. NORS (Nitric Oxide Releasing Solution)
  3. Lopinavir/ritonavir
    Hydroxychloroquine sulfate
    Baricitinib (janus kinase inhibitor)
  4. Lopinavir/ritonavir
  5.  Icosapent ethyl


  1. Ruxolitinib
  2. Hydroxychloroquine
  3. Hyperbaric oxygen
  4. Biological: BNT162a1
    Biological: BNT162b1
    Biological: BNT162b2
    Biological: BNT162c2


  1. Biological: convalescent plasma
  2. Biological: Convalescent Plasma of patients with COVID-19 and Other: placebo (hartmann plus albumine)
  3. Biological: Plasma
  4. Tocilizumab
  5. Biological: Infusion IV of Mesenchymal Stem cells
  6. Convalescent plasma
  7. Ruxolitinib Oral Tablet
  8. Pyridostigmine Bromide
  9. Colchicine


  1. ArtemiC


  1. Tocilizumab Injection
  2. Colchicine 1 MG Oral Tablet
  3. Biological: Emapalumab
    Biological: Anakinra
  4. Radiation: Single fraction whole lung radiotherapy
  5. Hydroxychloroquine
  6. Other: plasma hyperimmune
  7. Biological: COVID-19 Convalescent Plasma
  8. Oxygen-ozone therapy, probiotic supplementation and Standard of care
    Dietary Supplement: SivoMixx (200 billion)
  9. Colchicine
  10. Convalescent plasma
  11. Bevacizumab Injection
  12. Escin


  1. Best supportive Care (BSC) + IFX-1 and Best supportive care only
  2. Biological: Convalescent plasma


  1. Procedure: Convalescent Plasma
  2. T3 solution for injection
  3. Biological: Mesenchymal cells
  4. Clarithromycin
  5. Anakinra
  6. Anakinra
  7. Telerehabilitation


  1. DFV890
  2. Dietary Supplement: Nicotinamide riboside
    Dietary Supplement: Placebo
  3. RoActemra iv
    RoActemra sc
    Kevzara sc
  4. Camostat Mesilate


  1. Azithromycin 500 milligram (mg) oral Tablet
  2. RhACE2 APN01
  3. Chloroquine or Hydroxychloroquine


  1. Biological: Convalescent plasma
  2. Favipiravir


  1. Biological: COVID-19 convalescent plasma

Saudi Arabia

  1. convalescent plasma from recovered COVID 19 donor
  2. Hydroxychloroquine
  3. Dietary Supplement: Nigella sativa


  1. Tocilizumab (TCZ)


  1. Biological: SARS-CoV-2 convalescent plasma


  1. Telmisartan arm will receive 80 mg Telmisartan twice daily plus standard care.
  2. IVERMECTIN (IVER P®) arm will receive IVM 600 µg / kg once daily


  1. Dietary Supplement: Viusid and Asbrip


  1. Biological: SARS-CoV-2 rS
    Other: Matrix-M Adjuvant
    Other: NSS Saline Placebo

Russian Federation

  1. Biological: COVID-19 convalescent hyperimmune plasma
    Biological: Non-convalescent fresh frozen plasma (Standard plasma)
  2. Melphalan
  3. RPH-104 80 mg
    Olokizumab 64 mg
  4. Colchicine
    Ruxolitinib 5 MG
    Secukinumab 150 MG/ML Subcutaneous Solution [COSENTYX]
  5. Azoximer bromide


  1. Chloroquine phosphate


  1. Colchicine Tablets
  2. Deferoxamine
  3. Oral administration of Colchicine plus Herbal Phenolic Monoterpene Fractions
  4. Levamisole Pill + Budesonide+Formoterol inhaler
    Lopinavir/Ritonavir + hydoxychloroquine
  5. Oral 25-Hydroxyvitamin D3
  6. Low Dose Radiotherapy


  1. Hydroxychloroquine Sulfate 200 MG


  1. Amiodarone

Bosnia and Herzegovina

  1. metenkefalin + tridecactide


  1. Chloroquine Diphosphate
  2. Methylprednisolone Sodium Succinate


  1. Hydroxychloroquine


  1. MSC Treatment

It should be noted that this list is under development and it is not intended to be exhaustive. 

US Food and Drug Administration (FDA)

Last Updated: 2020-06-07

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